Gemtuzumab ozogamicin (Mylotarg) upregulates tissue factor expression but not secretion of inflammatory cytokines TNF-alpha or IL-8.

Johanna C Bruneau, Aengus O'Marcaigh, Owen P Smith

Department of Haematology, Trinity College, Dublin, Ireland.

Leukemia research 2010 Sep

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Gemtuzumab ozogamicin (GO; Mylotarg (R)) is an antibody-targeted chemotherapeutic agent approved for the treatment of CD33+ acute myelogenous leukemia (AML). GO is more commonly associated with the development of Sinusoidal Obstructive Syndrome (SOS) than any other chemotherapeutic agent in this patient group. Previous investigations have shown that SOS is a pro-coagulant and pro-inflammatory syndrome. Treatment of THP1 cells (CD33+ AML cell line) with GO alone, or in combination with unconjugated CD33 antibody (hP67.6), resulted in a statistically significant (P<0.01) increase in tissue factor (TF) expression, but HepG2 cells (CD33 hepatocyte cell line) were unaffected. Cytokine secretion was not affected by GO treatment in either cell line. These results indicate that GO exerts a pro-coagulant response in certain cell types, which may predispose individuals to developing SOS. Copyright 2010 Elsevier Ltd. All rights reserved.

Citation

Johanna C Bruneau, Aengus O'Marcaigh, Owen P Smith. Gemtuzumab ozogamicin (Mylotarg) upregulates tissue factor expression but not secretion of inflammatory cytokines TNF-alpha or IL-8. Leukemia research. 2010 Sep;34(9):1232-4