An electrophysiological study of the intermediate syndrome of organophosphate poisoning.

Paulo José Lorenzoni, Juliano Gasparetto, Cláudia Suemi Kamoi Kay, Rosana Herminia Scola, Lineu César Werneck

Division of Neurology, Department of Internal Medicine, Hospital de Clínicas da Universidade Federal do Paraná (UFPR), Rua General Carneiro 181, Curitiba PR 80060-900, Brazil.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2010 Sep

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Acute organophosphate (OP) poisoning is commonly seen in emergency medicine. Neurologists must be alert to detect neuromuscular transmission failure and other neurological complications that follow OP poisoning. We report a 37-year-old male with acute OP poisoning to emphasize the electrophysiological abnormalities during the intermediate syndrome (IMS). Motor nerve conduction studies revealed that a single nerve stimulation evoked a repetitive compound muscle action potential, whereas repetitive nerve stimulation resulted in a combination of a decrement-increment pattern and a repetitive fade response. Thus, electrophysiological studies can be used to monitor patients with IMS, and these test results correlate well with clinical findings in acute OP poisoning. Copyright 2010 Elsevier Ltd. All rights reserved.

Citation

Paulo José Lorenzoni, Juliano Gasparetto, Cláudia Suemi Kamoi Kay, Rosana Herminia Scola, Lineu César Werneck. An electrophysiological study of the intermediate syndrome of organophosphate poisoning. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2010 Sep;17(9):1217-9