Committee on Immunology, University of Chicago, 5841 S. Maryland, Chicago, IL 60637, USA. s-blink@northwestern.edu
Cellular immunology 2010Asthma and allergy are characterized by dysregulation of inflammatory responses toward Th2 responses and high serum levels of IgE. IgE plays a role in the effector phase by triggering the degranulation of mast cells after antigen-crosslinking but its role in the induction of helper T cell differentiation is unknown. We have previously shown lymphotoxin is required for maintaining physiological levels of serum IgE</a> which minimize spontaneous Th1-mediated airway inflammation, suggesting a physiological role for IgE in the regulation of T helper cell differentiation. We describe the mechanism in which IgE modulates inflammation by regulating dendritic cell cytokine production. Physiological levels of IgE suppress IL-12 production in the spleen and lung, suggesting IgE limits Th1 responses in vivo. IgE directly stimulates dendritic cells through FcgammaRIII to suppress IL-12 in vitro and influences APC to skew CD4+ T cells toward Th2 differentiation. We demonstrate a novel role for IgE in regulating differentiation of adaptive inflammatory responses through direct interaction with FcgammaRIII on dendritic cells. 2010 Elsevier Inc. All rights reserved.
Sarah E Blink, Yang-Xin Fu. IgE regulates T helper cell differentiation through FcgammaRIII mediated dendritic cell cytokine modulation. Cellular immunology. 2010;264(1):54-60
PMID: 20494341
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