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Adult onset Still's disease (AOSD) is a systemic inflammatory disease characterized by high-fevers, articular involvement, maculopapular rash, hepatosplenomegaly, lymphadenopathy, and a neutrophilic leukocytosis. Though systemic complications of AOSD or its treatment are well described in the literature, CNS involvement in AOSD is exceedingly rare and can have protean manifestations. We present a patient with AOSD who developed chronic meningitis and sensorineural hearing loss on treatment, with a review of prior reported cases of aseptic meningitis, to highlight this rare complication of this uncommon illness.

Citation

Bharath Manu Akkara Veetil, Alan H Yee, Kenneth J Warrington, Allen J Aksamit, Thomas G Mason. Aseptic meningitis in adult onset Still's disease. Rheumatology international. 2012 Dec;32(12):4031-4

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PMID: 20495923

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