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An enantioseparation study of nitro-substituted aryloxyaminopropanols was performed using HPLC on a teicoplanin chiral stationary phase and TLC impregnated with L-aspartic and L-tartaric acid as chiral selectors. The type of substituent on the nitrogen in the hydrophilic part of molecule is essential for excellent separation by HPLC. L-aspartic acid seems to be a suitable chiral selector for enantioseparation by TLC.


R Cizmáriková, K Bruchatá, Z Pastírová, J Lehotay, K Hrobonová. HPLC and TLC enantioseparation of the nitro-positioned aryloxysubstituted aminopropanols. Die Pharmazie. 2010 May;65(5):387-8

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PMID: 20503935

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