HPLC and TLC enantioseparation of the nitro-positioned aryloxysubstituted aminopropanols.

R Cizmáriková, K Bruchatá, Z Pastírová, J Lehotay, K Hrobonová

Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. cizmarikova@fpharm.uniba.sk

Die Pharmazie 2010 May

filter terms:

An enantioseparation study of nitro-substituted aryloxyaminopropanols was performed using HPLC on a teicoplanin chiral stationary phase and TLC impregnated with L-aspartic and L-tartaric acid as chiral selectors. The type of substituent on the nitrogen in the hydrophilic part of molecule is essential for excellent separation by HPLC. L-aspartic acid seems to be a suitable chiral selector for enantioseparation by TLC.

Citation

R Cizmáriková, K Bruchatá, Z Pastírová, J Lehotay, K Hrobonová. HPLC and TLC enantioseparation of the nitro-positioned aryloxysubstituted aminopropanols. Die Pharmazie. 2010 May;65(5):387-8