Serotonin receptor 3A expression in normal and neoplastic B cells.

Chromosome 11q21-qter is a very gene-rich region and is often targeted by genomic aberrations in a variety of human cancers, including B cell lymphoid neoplasms. In order to identify genes which could be deregulated in diffuse large B cell lymphomas (DLBCL), we analyzed the expression levels of genes mapped on chromosome 11q21-qter across a series of publicly available DLBCL expression data sets. We identified HTR3A, the gene coding for 5-hydroxytryptamine receptor 3A, as the most frequently differentially expressed. Since HTR3A expression had not been previously characterized in normal and neoplastic B cells, we evaluated its expression by real-time PCR and by immunohistochemistry. The gene is expressed by B cells and it seems to be regulated during the mature B cell differentiation, being overexpressed during the germinal center phase. Lymphomas derived from germinal center B cells maintain the expression, with the level of expression varying among different patients. 2010 S. Karger AG, Basel.

Citation

Andrea Rinaldi, Anna Maria Chiaravalli, Michael Mian, Emanuele Zucca, Maria Grazia Tibiletti, Carlo Capella, Francesco Bertoni. Serotonin receptor 3A expression in normal and neoplastic B cells. Pathobiology : journal of immunopathology, molecular and cellular biology. 2010;77(3):129-35

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PMID: 20516728

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