Electrophilic aromatic selenylation: new OPRT inhibitors.

Mohannad Abdo, Yong Zhang, Vern L Schramm, Spencer Knapp

Department of Chemistry & Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, USA.

Organic letters 2010 Jul 2

filter terms:

2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase.

Citation

Mohannad Abdo, Yong Zhang, Vern L Schramm, Spencer Knapp. Electrophilic aromatic selenylation: new OPRT inhibitors. Organic letters. 2010 Jul 2;12(13):2982-5