Electrophilic aromatic selenylation: new OPRT inhibitors.

2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase.

Citation

Mohannad Abdo, Yong Zhang, Vern L Schramm, Spencer Knapp. Electrophilic aromatic selenylation: new OPRT inhibitors. Organic letters. 2010 Jul 02;12(13):2982-5

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PMID: 20521773

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