Regulation of mRNA translation and stability by microRNAs.

Marc Robert Fabian, Nahum Sonenberg, Witold Filipowicz

Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Quebec, H3G 1Y6, Canada. marc.fabian@mail.mcgill.ca

Annual review of biochemistry 2010

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MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base-pairing to the mRNA 3'-untranslated regions to repress protein synthesis by mechanisms that are not fully understood. In this review, we describe principles of miRNA-mRNA interactions and proteins that interact with miRNAs and function in miRNA-mediated repression. We discuss the multiple, often contradictory, mechanisms that miRNAs have been reported to use, which cause translational repression and mRNA decay. We also address the issue of cellular localization of miRNA-mediated events and a role for RNA-binding proteins in activation or relief of miRNA repression.

Citation

Marc Robert Fabian, Nahum Sonenberg, Witold Filipowicz. Regulation of mRNA translation and stability by microRNAs. Annual review of biochemistry. 2010;79:351-79