For some time, post-translational small protein modifications were found only in eukaryotes; much later, such modifications were identified in some species of bacteria. The recent discovery of ubiquitin-like proteins that form polymeric chains and covalently modify proteins in archaea finally closes the evolutionary gap among the domains of life. Copyright 2010 Elsevier Ltd. All rights reserved.
K Heran Darwin, Kay Hofmann. SAMPyling proteins in archaea. Trends in biochemical sciences. 2010 Jun;35(6):348-51
PMID: 20547064
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