SAMPyling proteins in archaea.

Department of Microbiology, New York University School of Medicine, 550 First Avenue MSB 236, New York, NY 10016, USA. heran.darwin@med.nyu

Trends in biochemical sciences 2010 Jun

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For some time, post-translational small protein modifications were found only in eukaryotes; much later, such modifications were identified in some species of bacteria. The recent discovery of ubiquitin-like proteins that form polymeric chains and covalently modify proteins in archaea finally closes the evolutionary gap among the domains of life. Copyright 2010 Elsevier Ltd. All rights reserved.