Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France.

Didier Hocquet, Patrick Plésiat, Barbara Dehecq, Pierre Mariotte, Daniel Talon, Xavier Bertrand, ONERBA

Centre National de Référence de la Résistance aux Antibiotiques, Laboratoire associé P. aeruginosa, Hôpital Jean Minjoz, Besançon, France. dhocquet@univ-fcomte.fr

Antimicrobial agents and chemotherapy 2010 Aug

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A nationwide study aimed to identify the extended-spectrum beta-lactamases (ESBLs), metallo-beta-lactamases (MBLs), and extended-spectrum oxacillinases (ES-OXAs) in a French collection of 140 clinical Pseudomonas aeruginosa isolates highly resistant to ceftazidime. Six ESBLs (PER-1, n=3; SHV-2a, n=2; VEB-1a, n=1), four MBLs (VIM-2, n=3; IMP-18, n=1), and five ES-OXAs (OXA-19, n=4; OXA-28, n=1) were identified in 13 isolates (9.3% of the collection). The prevalence of these enzymes is still low in French clinical P. aeruginosa isolates but deserves to be closely monitored.

Citation

Didier Hocquet, Patrick Plésiat, Barbara Dehecq, Pierre Mariotte, Daniel Talon, Xavier Bertrand, ONERBA. Nationwide investigation of extended-spectrum beta-lactamases, metallo-beta-lactamases, and extended-spectrum oxacillinases produced by ceftazidime-resistant Pseudomonas aeruginosa strains in France. Antimicrobial agents and chemotherapy. 2010 Aug;54(8):3512-5