Synthesis and anti-inflammatory activity of some 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives.

Santosh N Mokale, Sandeep S Shinde, Rupali D Elgire, Jaiprakash N Sangshetti, Devanand B Shinde

Dr. Rafiq Zakaria Campus, Y.B. Chavan College of Pharmacy, Aurangabad 431 001 (M.S.), India. santoshmokale@rediffmail.com

Bioorganic & medicinal chemistry letters 2010 Aug 1

filter terms:

A series of 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives has been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5-oxopentanoic acid and substituted aldehyde. The synthesized compounds were screened for their anti-inflammatory activity using rat paw edema method. Most of the compounds from the series showed significant (p <0.05) anti-inflammatory activity. Copyright 2010 Elsevier Ltd. All rights reserved.

Citation

Santosh N Mokale, Sandeep S Shinde, Rupali D Elgire, Jaiprakash N Sangshetti, Devanand B Shinde. Synthesis and anti-inflammatory activity of some 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives. Bioorganic & medicinal chemistry letters. 2010 Aug 1;20(15):4424-6