Olfactory type G-protein alpha subunit in striosome-matrix dopamine systems in adult mice.

W Sako, R Morigaki, S Nagahiro, R Kaji, S Goto

Parkinson's Disease and Dystonia Research Center, Tokushima University Hospital, Tokushima 770-8503, Japan; Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medical Sciences, University of Tokushima, Tokushima 770-8503, Japan.

Neuroscience 2010 Oct 13

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There is a growing body of evidence that striosome-matrix dopamine systems are tightly linked with motor and behavioral brain functions and disorders. In this study, we used an immunohistochemical method to show differential expression of the olfactory type G-protein alpha subunit (Galphaolf) that involves in the coupling of dopamine D1 receptor with adenylyl cyclase in the striatal compartments of adult mice, and observed heightened density of Galphaolf labeling in the striosomes relative to the matrix compartment. Our findings suggest that Galphaolf could be one of the key molecules for controlling differential responses of the striosome and matrix compartments to dopamine D1 receptor signaling in the striatum of adult mice. Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.

Citation

W Sako, R Morigaki, S Nagahiro, R Kaji, S Goto. Olfactory type G-protein alpha subunit in striosome-matrix dopamine systems in adult mice. Neuroscience. 2010 Oct 13;170(2):497-502