Platelet aggregation inhibitors from the seeds of Swietenia mahagoni: inhibition of in vitro and in vivo platelet-activating factor-induced effects of tetranortriterpenoids related to swietenine and swietenolide.

H Ekimoto, Y Irie, Y Araki, G Q Han, S Kadota, T Kikuchi

Research Laboratories, Nippon Kayaku Co., Ltd., Tokyo, Japan.

Planta medica 1991 Feb

filter terms:

The ether extract from the seeds of Swietenia mahagoni Jacq. (Meliaceae) was found to inhibit platelet-activating factor (PAF)-induced platelet aggregation. Systematic separation of the extract afforded twenty eight tetranortriterpenoids related to swietenine and swietenolide. Among them, several new compounds, named swietemahonin A, D, E, and G and 3-O-acetylswietenolide and 6-O-acetylswietenolide, showed a strong inhibition against PAF-induced aggregation in vitro and in vivo assays.

Citation

H Ekimoto, Y Irie, Y Araki, G Q Han, S Kadota, T Kikuchi. Platelet aggregation inhibitors from the seeds of Swietenia mahagoni: inhibition of in vitro and in vivo platelet-activating factor-induced effects of tetranortriterpenoids related to swietenine and swietenolide. Planta medica. 1991 Feb;57(1):56-8