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Hippuric acid is the primary metabolite of toluene, a solvent widely used in industrial processes with considerable toxic effects, a fact which justifies regularly monitoring individuals with occupational exposure to this solvent. This work aims at evaluating urinary hippuric acid levels found in workers subject to biological monitoring. A retrospective study was carried out with data referring from 2002 to 2005, in which exams results and employment status were analyzed (periodic, post-employment, and pre-employment exams). Results indicate a significant reduction in hippuric acid levels for 2005. Periodic exams presented higher results than pre-employment and post-employment exams. No significant difference was found in individuals grouped according to their status in each of the established intervals, their reference numbers, and maximum biological levels allowed. Hippuric acid levels detected indicate low risk of toluene exposure for the population under evaluation, probably due to a growing concern with the deployment of measures regarding occupational hygiene.


Kelly Cristina Gonzalez, Fernando Rodrigues Sagebin, Paola Garcia Oliveira, Luiz Glock, Flavia Valladão Thiesen. A retrospective study analysis of urinary hippuric acid levels in occupational toxicology exams]. Ciência & saúde coletiva. 2010 Jun;15 Suppl 1:1637-41

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PMID: 20640325

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