Electric field-driven disruption of a native beta-sheet protein conformation and generation of a helix-structure.

Pedro Ojeda-May, Martin E Garcia

Theoretische Physik, Universität Kassel, Fachbereich 10, Kassel, Germany. pojeda@physik.uni-kassel.de

Biophysical journal 2010 Jul 21

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We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate states of the protein. Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Citation

Pedro Ojeda-May, Martin E Garcia. Electric field-driven disruption of a native beta-sheet protein conformation and generation of a helix-structure. Biophysical journal. 2010 Jul 21;99(2):595-9