Premarin improves outcomes of spinal cord injury in male rats through stimulating both angiogenesis and neurogenesis.

Sheng-Hsien Chen, Chao-Hung Yeh, Mike Yang-Sheng Lin, Chieh-Yi Kang, Chin-Chen Chu, Fong-Ming Chang, Jhi-Joung Wang

Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan. 891201@mail.chimei.org.tw

Critical care medicine 2010 Oct

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To ascertain whether Premarin improves spinal cord injury outcomes in male rats by stimulating both angiogenesis and neurogenesis. Chi Mei Medical Center research laboratory. Male Sprague-Dawley rats 240-258 g. Anesthetized rats, after the onset of spinal cord injury, were divided into two groups and given the vehicle solution (1 mL/kg of body weight) or Premarin (1 mg/kg of body weight). Saline or Premarin solutions were administered intravenously and immediately after spinal cord injury. Premarin (an estrogen sulfate) causes attenuation of spinal cord injury-induced spinal cord infarction and hind limb locomotor dysfunction. Spinal cord injury-induced apoptosis as well as activated inflammation was also significantly Premarin-reduced. In injured spinal cord, angiogenesis, neurogenesis, and production of an antiinflammatory cytokine were all Premarin therapy-promoted. Our results indicate that Premarin therapy may protect against spinal cord apoptosis after spinal cord injury through mechanisms stimulating both angiogenesis and neurogenesis in male rats.

Citation

Sheng-Hsien Chen, Chao-Hung Yeh, Mike Yang-Sheng Lin, Chieh-Yi Kang, Chin-Chen Chu, Fong-Ming Chang, Jhi-Joung Wang. Premarin improves outcomes of spinal cord injury in male rats through stimulating both angiogenesis and neurogenesis. Critical care medicine. 2010 Oct;38(10):2043-51