Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2.
Csaba Földy, Sang-Hun Lee, Robert J Morgan, Ivan Soltesz
Department of Anatomy and Neurobiology, University of California, Irvine, California, USA. foldy@stanford.edu
Nature neuroscience 2010 SepParvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.
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Csaba Földy, Sang-Hun Lee, Robert J Morgan, Ivan Soltesz. Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2. Nature neuroscience. 2010 Sep;13(9):1047-9
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PMID: 20676104
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