Synthesis of pseudodeflectusin and ustusorane C: structural revision of aspergione a and B.

Kouji Kuramochi, Fumiyo Saito, Atsuo Nakazaki, Toshifumi Takeuchi, Kazunori Tsubaki, Fumio Sugawara, Susumu Kobayashi

Graduate School of Life and Environmental Science, Kyoto Prefectural University, Kyoto, Japan.

Bioscience, biotechnology, and biochemistry 2010

filter terms:

The syntheses of racemic and optically active pseudodeflectusin and ustusorane C are described. The (1)H- and (13)C-NMR data for our synthetic pseudodeflectusin and ustusorane C were identical to those of the corresponding natural products. We also synthesized the proposed structure of aspergione A and B whose (1)H- and (13)C-NMR data were identical to those of ustusorane C and pseudodeflectusin. The (1)H- and (13)C-NMR spectra of our synthetic aspergione A and B were different from those of the natural compounds. Our results confirm that aspergione A and B are in fact ustusorane C and pseudodeflectusin, respectively.

Citation

Kouji Kuramochi, Fumiyo Saito, Atsuo Nakazaki, Toshifumi Takeuchi, Kazunori Tsubaki, Fumio Sugawara, Susumu Kobayashi. Synthesis of pseudodeflectusin and ustusorane C: structural revision of aspergione a and B. Bioscience, biotechnology, and biochemistry. 2010;74(8):1635-40