Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.

Akiyuki Ikedo, Ichiro Hayakawa, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, Hideo Kigoshi

Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan.

Bioorganic & medicinal chemistry letters 2010 Sep 15

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Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3 cells was investigated. Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Citation

Akiyuki Ikedo, Ichiro Hayakawa, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, Hideo Kigoshi. Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells. Bioorganic & medicinal chemistry letters. 2010 Sep 15;20(18):5402-4