Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant rats.

Kiran B Tam Tam, Babbette Lamarca, Marietta Arany, Kathy Cockrell, Lillian Fournier, Sydney Murphy, James N Martin, Joey P Granger

Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA.

American journal of hypertension 2011 Jan

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Preeclampsia is associated with increased levels of reactive oxygen species (ROS) and the antiangiogenic factor, soluble fms-like tyrosine kinase-1 (sFlt-1). Moreover, recent studies have indicated that chronic sFlt-1 excess causes hypertension in pregnant animals. The purpose of this study was to evaluate the role of ROS in mediating sFlt-1-induced hypertension in the pregnant rat. Mean arterial pressure (MAP), and plasma sFlt-1 and tissue ROS levels were measured in the following groups: (i) pregnant controls; (ii) sFlt-1-treated pregnant rats; (iii) Tempol-treated pregnant rats; (iv) sFlt-1- and Tempol-treated pregnant rats. MAP increased from 104 ± 2 mm Hg in pregnant control rats to 118 ± 3 mm Hg (P = 0.002) in sFlt-1-infused rats. Basal and nicotinamide adenine dinucleotide phosphate (NADPH)-stimulated levels of tissue ROS were increased in response to excess sFlt-1 during pregnancy. Pretreatment with Tempol attenuated oxidative stress and hypertension in response to sFlt-1. ROS play an important role in mediating hypertension in response to chronic sFlt-1 excess during pregnancy.

Citation

Kiran B Tam Tam, Babbette Lamarca, Marietta Arany, Kathy Cockrell, Lillian Fournier, Sydney Murphy, James N Martin, Joey P Granger. Role of reactive oxygen species during hypertension in response to chronic antiangiogenic factor (sFlt-1) excess in pregnant rats. American journal of hypertension. 2011 Jan;24(1):110-3