Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse.

miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes. Copyright © 2010 Elsevier Inc. All rights reserved.

Citation

Brenda J Polster, Shawn K Westaway, Thuy M Nguyen, Moon Y Yoon, Susan J Hayflick. Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse. Molecular genetics and metabolism. 2010 Oct-Nov;101(2-3):292-5

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PMID: 20729113

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