Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ.

Dong-Wook Kim, Kee-Beom Kim, Ji-Young Kim, Kyu-Sun Lee, Sang-Beom Seo

Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-756, South Korea.

Biochemical and biophysical research communications 2010 Sep 24

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Epigenetic modification plays an important role in transcriptional regulation. As a subunit of the INHAT (inhibitor of histone acetyltransferases) complex, SET/TAF-Iβ evidences transcriptional repression activity. In this study, we demonstrate that SET/TAF-Iβ is abundantly expressed in neuronal tissues of Drosophila embryos. It is expressed at high levels prior to and in early stages of neuronal development, and gradually reduced as differentiation proceeds. SET/TAF-Iβ binds to the promoters of a subset of neuronal development markers and negatively regulates the transcription of these genes. The results of this study show that the knockdown of SET/TAF-Iβ by si-RNA induces neuronal cell differentiation, thus implicating SET/TAF-Iβ as a negative regulator of neuronal development. Copyright © 2010 Elsevier Inc. All rights reserved.

Citation

Dong-Wook Kim, Kee-Beom Kim, Ji-Young Kim, Kyu-Sun Lee, Sang-Beom Seo. Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ. Biochemical and biophysical research communications. 2010 Sep 24;400(3):419-25