A simple chromatographic route for the isolation of meso diaminopimelic acid.

Gábor K Tóth, Anasztázia Hetényi, István Ilisz, Antal Péter

Department of Medical Chemistry, University of Szeged, Szeged, Hungary.

Chirality 2011 Feb

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Meso diaminopimelic acid is an important noncoded amino acid found in Gram-negative bacterial peptidoglycan. In spite of its importance, this stereoisomer is not available commercially. A simple, economical procedure was developed for the isolation of pure meso diaminopimelic acid via an high-performance liquid chromatography separation. In our new approach, the underivatized three isomers of diaminopimelic acid were separated on a crown ether-based chiral stationary phase. For the structure identification, (1)H NMR spectroscopy was applied. Copyright © 2010 Wiley-Liss, Inc.

Citation

Gábor K Tóth, Anasztázia Hetényi, István Ilisz, Antal Péter. A simple chromatographic route for the isolation of meso diaminopimelic acid. Chirality. 2011 Feb;23(2):133-7