Phosphotyrosine signaling: evolving a new cellular communication system.

Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans. Copyright 2010 Elsevier Inc. All rights reserved.

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Wendell A Lim, Tony Pawson. Phosphotyrosine signaling: evolving a new cellular communication system. Cell. 2010 Sep 03;142(5):661-7

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PMID: 20813250

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