Therapeutic efficacy of Nexavar on liver cancer and its relation to the expression of Ki-67 and CD34].

To study the therapeutic effects of Nexavar on liver cancer and its relation to the expressions of Ki-67 and CD34. Twenty-eight patients with liver cancer were treated with Nexavar. The therapeutic efficacy of Nexavar on liver cancer was observed. Liver cancer tissues were examined for the expressions of Ki-67 and CD34 by immunohistochemistry. Microvessel density (MVD) was calculated according to the expression of CD34. Of 28 patients, none achieved a complete response (CR), 12 had a partial response (PR), 7 had stable disease (SD), and 9 progressive disease (PD). The efficacy of Nexavar was associated significantly with Ki-67 expression. The mean MVD count was 346.03-/+146.98 in PR patients, and 89.14-/+45.66 in PD patients. There was a significant difference in MVD between PR and PD patients. There is a better efficacy of Nexavar in treatment of liver cancer in the patients who had Ki-67-positive expression and high MVD count.

Citation

He-ping Kan, Yu Wang, Yong-fa Tan, Jie Zhou. Therapeutic efficacy of Nexavar on liver cancer and its relation to the expression of Ki-67 and CD34]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2010 Aug;30(8):1930-1, 1934

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PMID: 20813706

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