Studies on pharmacologically active principles from Indonesian crude drugs. III. Toxic components from Brucea javanica (L.) Merr].

E Okuyama, L H Gao, M Yamazaki

Faculty of Pharmaceutical Sciences, Chiba University, Japan.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1990 Nov

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During our screening of pharmacologically active principles from Indonesian medicinal plants by a hypothermic effect the methanol-extract of Brucea javanica (L.) Merr. has been found to exhibit a lethal toxicity to mice. The toxic components were isolated and identified with bruceoside A and B and yadanzioside F. Correction of 13C-nuclear magnetic resonance assignment was also mentioned.

Citation

E Okuyama, L H Gao, M Yamazaki. Studies on pharmacologically active principles from Indonesian crude drugs. III. Toxic components from Brucea javanica (L.) Merr]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1990 Nov;110(11):834-8