Comparing peripheral glial cell differentiation in Drosophila and vertebrates.

In all complex organisms, the peripheral nerves ensure the portage of information from the periphery to central computing and back again. Axons are in part amazingly long and are accompanied by several different glial cell types. These peripheral glial cells ensure electrical conductance, most likely nature the long axon, and establish and maintain a barrier towards extracellular body fluids. Recent work has revealed a surprisingly similar organization of peripheral nerves of vertebrates and Drosophila. Thus, the genetic dissection of glial differentiation in Drosophila may also advance our understanding of basic principles underlying the development of peripheral nerves in vertebrates.

Citation

Floriano Rodrigues, Imke Schmidt, Christian Klämbt. Comparing peripheral glial cell differentiation in Drosophila and vertebrates. Cellular and molecular life sciences : CMLS. 2011 Jan;68(1):55-69

Mesh Tags

PMID: 20820850

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