Biochemical and cellular functions of P4 ATPases.

Lieke M van der Velden, Stan F J van de Graaf, Leo W J Klomp

Department of Metabolic and Endocrine Diseases, UMC Utrecht, and Netherlands Metabolomics Centre, Utrecht, 3508 AB, The Netherlands.

The Biochemical journal 2010 Oct 1

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P4 ATPases (subfamily IV P-type ATPases) form a specialized subfamily of P-type ATPases and have been implicated in phospholipid translocation from the exoplasmic to the cytoplasmic leaflet of biological membranes. Pivotal roles of P4 ATPases have been demonstrated in eukaryotes, ranging from yeast, fungi and plants to mice and humans. P4 ATPases might exert their cellular functions by combining enzymatic phospholipid translocation activity with an enzyme-independent action. The latter could be involved in the timely recruitment of proteins involved in cellular signalling, vesicle coat assembly and cytoskeleton regulation. In the present review, we outline the current knowledge of the biochemical and cellular functions of P4 ATPases in the eukaryotic membrane.

Citation

Lieke M van der Velden, Stan F J van de Graaf, Leo W J Klomp. Biochemical and cellular functions of P4 ATPases. The Biochemical journal. 2010 Oct 1;431(1):1-11