Antiretroviral therapy abrogates association between arginase activity and HIV disease severity.

T E Cloke, T Abebe, A Hailu, M Munder, G P Taylor, I Müller, P Kropf

Department of Immunology, Imperial College London, London W2 1PG, UK.

Transactions of the Royal Society of Tropical Medicine and Hygiene 2010 Nov

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Arginase-induced L-arginine deprivation is emerging as a key mechanism for the downregulation of immune responses. We hypothesised that arginase activity increases with disease severity in HIV-seropositive patients. Our results show that peripheral blood mononuclear cells (PBMCs) from 23 HIV-seropositive patients with low CD4(+) T cell counts (≤350 cells/μl) expressed significantly more arginase compared with 21 patients with high CD4(+) T cell counts. Furthermore, we found a significant association between the two principal prognostic markers used to monitor HIV disease (CD4(+) T cell count and plasma viral load) and PBMC arginase activity in antiretroviral therapy naïve patients but not in patients undergoing therapy. Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.

Citation

T E Cloke, T Abebe, A Hailu, M Munder, G P Taylor, I Müller, P Kropf. Antiretroviral therapy abrogates association between arginase activity and HIV disease severity. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2010 Nov;104(11):746-8