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To investigate the association between IL-1beta and DVWA gene and Kashin-Beck disease (KBD). Peripheral genomic DNA were extracted from 105 patients with KBD and 98 healthy controls. PCR-RFLP were performed to detect SNP loci of IL-1beta gene and DVWA gene. The patients with KBD had significantly higher frequency of rs16944 (IL-1beta) locus (chi2 = 24.28, P < 0.001) and single allele frequency of rs16944 (chi2 = 5.683, P = 0.0171) than the healthy controls. There were no significant differences in genotype frequencies,single allele frequencies and haplotypes in rs4685241 and rs1143627 between the patients with KBD and the healthy controls. rs16944 (IL-1beta) is associated with KBD.


Min Y U, Xiong Guo, Xiao-Yun Gao, Jiang-Hua Lai, Qian-Qian Tu. Association between polymorphism in DVWA and IL-1beta and Kashin-Beck disease]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2010 Jul;41(4):669-73

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PMID: 20848793

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