Antiarrhythmic activity of novel S-enantiomers of pyrrolidin-2-one derivatives with adrenolytic properties.

A six new analogs of MG-1(S), 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, with adrenolytic properties were tested for electrocardiographic and antiarrhythmic activity in model ventricular arrhythmias associated with coronary artery occlusion and reperfusion in the non-working isolated perfused rat heart and additionally in barium chloride-induced arrhythmia in vivo. All tested compounds slightly decreased the heart rate, prolonged P-Q, Q-T intervals and QRS complex. The antiarrhythmic effects of all tested compounds were weaker than the reference compound MG-1(S).

Citation

Jacek Sapa. Antiarrhythmic activity of novel S-enantiomers of pyrrolidin-2-one derivatives with adrenolytic properties. Acta poloniae pharmaceutica. 2010 Sep-Oct;67(5):537-42

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PMID: 20873423

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