Decrease in acetylcholinergic neurons in the pedunculopontine tegmental nucleus in a patient with Prader-Willi syndrome.

Masaharu Hayashi, Rie Miyata, Naoyuki Tanuma

Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu-shi, Tokyo, Japan. hayashims@igakuken.or.jp

Neuropathology : official journal of the Japanese Society of Neuropathology 2011 Jun

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Prader-Willi syndrome (PWS) is caused by the absence of paternally contributed genes in chromosome 15, and is characterized by hypotonia, feeding difficulty, mental retardation, growth failure, hypogonadism and severe obesity. To elucidate the pathogenesis of neurological disorders, we immunohistochemically examined the γ-aminobutyric acid (GABA)ergic interneurons (GABAis) in the cerebral cortex and acetylcholine neurons (AchNs) in the nucleus basalis of Meynert (MyN) and pedunculopontine tegmental nucleus pars compacta (PPNc) in an autopsy case of one PWS patient with a deletion in the 15q11-q12 region and three control patients. The GABAis in the cerebral cortex and AchNs in the MyN were well preserved in the PWS patient. The AchNs in the PPNc in the PWS patient were severely reduced in comparison with those in controls, whereas catecholaminergic neurons and GABAis were preserved. The selective loss of AchNs in the PPNc may be involved in hypotonia and/or REM sleep abnormalities in PWS patients. © 2010 Japanese Society of Neuropathology.

Citation

Masaharu Hayashi, Rie Miyata, Naoyuki Tanuma. Decrease in acetylcholinergic neurons in the pedunculopontine tegmental nucleus in a patient with Prader-Willi syndrome. Neuropathology : official journal of the Japanese Society of Neuropathology. 2011 Jun;31(3):280-5