A rapid and efficient ultrasound-assisted synthesis of 5,5-diphenylhydantoins and 5,5-diphenyl-2-thiohydantoins.

Naimeh Moshtael Arani, Javad Safari

Research Laboratory of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran.

Ultrasonics sonochemistry 2011 Mar

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To obtain a rapid, efficient and mild synthesis of 5,5-diphenylhydantoin and 5,5-diphenyl-2-thiohydantoin derivatives, ultrasonic irradiation has been applied to the reaction mixtures containing substituted benzils and urea or thiourea derivatives catalyzed by KOH in DMSO/H(2)O, which allowed us to achieve products at room temperature in a good yield and short time without any side product. This convenient procedure will allow a further increase of the diversity within the hydantoin family. Copyright © 2010 Elsevier B.V. All rights reserved.

Citation

Naimeh Moshtael Arani, Javad Safari. A rapid and efficient ultrasound-assisted synthesis of 5,5-diphenylhydantoins and 5,5-diphenyl-2-thiohydantoins. Ultrasonics sonochemistry. 2011 Mar;18(2):640-3