Drug-induced sexual dysfunction in rats.

Johnny S W Chan, Marcel D Waldinger, Berend Olivier, Ronald S Oosting

Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2010 Oct

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This unit describes the testing of sexual behaviors of male Wistar rats. The described test enables the detection of stimulatory and inhibitory profiles of compounds. The test includes four training sessions to reach a stable sexual performance, followed by acute and/or chronic administration of drugs. The main quantifiable sexual behaviors are number of mounts (no vaginal penetration), intromissions (vaginal penetration), and ejaculations. By comparing the test compound to reference compound(s), sexual (side) effects can be determined.

Citation

Johnny S W Chan, Marcel D Waldinger, Berend Olivier, Ronald S Oosting. Drug-induced sexual dysfunction in rats. Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]. 2010 Oct;Chapter 9:Unit 9.34