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Three new triterpenoid saponins, platyconic acid B lactone (1), deapio-platyconic acid B lactone (2), and deapio-platycodin D(2) (3), together with 17 known triterpenoid saponins, were isolated from a root extract of Platycodon grandiflorum. The structures of 1-3 were determined on the basis of spectroscopic data interpretation and chemical transformation. Saponins with a platycodigenin or polygalacic acid unit as a sapogenin demonstrated significant inhibitory effects on the proliferation of a small panel of cultured human tumor cells.


Yeon Hee Choi, Dae Seok Yoo, Mi-Ran Cha, Chun Whan Choi, Young Sup Kim, Sang-Un Choi, Kang Ro Lee, Shi Yong Ryu. Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells. Journal of natural products. 2010 Nov 29;73(11):1863-7

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PMID: 20939516

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