Flecainide-associated bradycardia-dependent torsade de pointes: another potential mechanism of proarrhythmia.

Although flecainide has a risk of proarrhythmia in patients with structural heart disease, its mechanism has been mainly ascribed to use-dependency and a rapid ventricular response to organized atrial tachyarrhythmias or to ventricular tachycardia. We present a patient who experienced recurrent syncope due to bradycardia-dependent torsade de pointes (TdP) associated with flecainide-related bradycardia and QT prolongation. Bradycardia-dependent TdP with QT prolongation can be considered as one of mechanisms of flecainide-induced proarrhythmia. ©2010, The Authors. Journal compilation ©2010 Wiley Periodicals, Inc.

Citation

Han Sang Kim, Hui-Nam Pak, Jong Seoung Park, Sung Soon Kim. Flecainide-associated bradycardia-dependent torsade de pointes: another potential mechanism of proarrhythmia. Pacing and clinical electrophysiology : PACE. 2013 Mar;36(3):e84-6

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PMID: 21029131

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