Inhibitory effect of total glucosides of paeonia on the NF-κB/p65 protein expression in paws of RA rats].

To explore effects of total glucosides of paeonia (TGP)on the NF-κB/p65 protein expression in paws of rheumatoid arthritis (RA) rats, and the contents of serum TNF-α, IL-1β and IL-10 in RA rats serum. Type II collagen-induced arthritis model in SD rats was established. The expression of NF-κB/p65 proteins in rat, s paw tissues was detected by immunohistochemical staining. The contents of serum TNF-α, IL-1β and IL-10 in RA rats were detected by ELISA. TGP could down-regulate the expression of NF-κB/ p65 protein and contents of TNF-α, IL-1β and IL-10 in RA rats. The inhibitory effect of TGP on anti-inflammation maybe related to decreasing the expression of NF-κB/p65 protein and suppressing the production of TNF-α and IL-1β in RA rats.

Citation

Guo-ling Liu, Yi-chuan Li, Yong-jie Shen. Inhibitory effect of total glucosides of paeonia on the NF-κB/p65 protein expression in paws of RA rats]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2010 Nov;26(11):1082-4

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PMID: 21055346

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