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Several projects were initiated by the Human Proteome Organisation (HUPO) focusing on the proteome analysis of distinct human organs. The initiative dedicated to the brain, its development and correlated diseases is the HUPO Brain Proteome Project (HUPO BPP). An objective data submission, storage, and reprocessing strategy have been established with the help of the results gained in a pilot study phase and within subsequent studies. The bioinformatic relevance of the data is drawn from the inter-laboratory comparisons as well as from the recalculation of all data sets submitted by the different groups. In the following, results of the single groups as well as the centralised reprocessing effort are summarised, demonstrating the added-value of this concerted work.


Michael Hamacher, Bernd Gröttrup, Martin Eisenacher, Katrin Marcus, Young Mok Park, Helmut E Meyer, Kyung-Hoon Kwon, Christian Stephan. Inter-lab proteomics: data mining in collaborative projects on the basis of the HUPO brain proteome project's pilot studies. Methods in molecular biology (Clifton, N.J.). 2011;696:235-46

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PMID: 21063951

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