Bekhterev St. Petersburg Psychoneurological Research Institute, St. Petersburg, 192019, Russia. eedubinina@rambler.ru
Biochemistry. Biokhimii͡a 2010 SepThe role of lipid peroxidation product 4-hydroxy-trans-2-nonenal (4-HNE) in functional activity of cells under normal and different pathological conditions is discussed. Different pathways of 4-HNE metabolism in tissues are analyzed, with particular focus on the role the glutathione system in this process. 4-HNE is implicated in regulation of cell growth, proliferation, differentiation, and apoptosis. 4-HNE and metabolic products of other antioxidants (carotenoids) resemble each other in chemical nature of the product and influence general pathways of signal transduction. Manifestation of 4-HNE toxicity under oxidative stress conditions is regarded as a link to many diseases whose pathogenesis is connected with modifications of proteins and nucleic acids.
E E Dubinina, V A Dadali. Role of 4-hydroxy-trans-2-nonenal in cell functions. Biochemistry. Biokhimii͡a. 2010 Sep;75(9):1069-87
PMID: 21077827
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