Joan Segura, Narcis Fernandez-Fuentes
Section of Experimental Therapeutics, Leeds Institute of Molecular Medicine, St James's University Hospital, University of Leeds, Leeds LS9 7TF, UK.
Nucleic acids research 2011 JanProtein-protein interactions are central to almost any cellular process. Although typically protein interfaces are large, it is well established that only a relatively small region, the so-called 'hot spot', contributes the most to the total binding energy. There is a clear interest in identifying hot spots because of its application in drug discovery and protein design. Presaging Critical Residues in Protein Interfaces Database (PCRPi-DB) is a public repository that archives computationally annotated hot spots in protein complexes for which the 3D structure is known. Hot spots have been annotated using a new and highly accurate computational method developed in the lab. PCRPi-DB is freely available to the scientific community at http://www.bioinsilico.org/PCRPIDB. Besides browsing and querying the contents of the database, extensive documentation and links to relevant on-line resources and contents are available to users. PCRPi-DB is updated on a weekly basis.
Joan Segura, Narcis Fernandez-Fuentes. PCRPi-DB: a database of computationally annotated hot spots in protein interfaces. Nucleic acids research. 2011 Jan;39(Database issue):D755-60
PMID: 21097468
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