Ubiquitin: same molecule, different degradation pathways.

Michael J Clague, Sylvie Urbé

Institute of Translational Medicine, University of Liverpool, UK. clague@liv.ac.uk

Cell 2010 Nov 24

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Ubiquitin is a common demoninator in the targeting of substrates to all three major protein degradation pathways in mammalian cells: the proteasome, the lysosome, and the autophagosome. The factors that direct a substrate toward a particular route of degradation likely include ubiquitin chain length and linkage type, which may favor interaction with particular receptors or confer differential susceptibility to deubiquitinase activities associated with each pathway. Copyright © 2010 Elsevier Inc. All rights reserved.