4-[18F]fluoroglutamic acid (BAY 85-8050), a new amino acid radiotracer for PET imaging of tumors: synthesis and in vitro characterization.

Institute of Human Brain of the Russian Academy of Science, St. Petersburg, Russia.

Journal of medicinal chemistry 2011 Jan 13

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There is a high demand for tumor specific PET tracers in oncology imaging. Besides glucose, certain amino acids also serve as energy sources and anabolic precursors for tumors. Therefore, (18)F-labeled amino acids are interesting probes for tumor specific PET imaging. As glutamine and glutamate play a key role in the adapted intermediary metabolism of tumors, the radiosynthesis of 4-[(18)F]fluoro l-glutamic acid (BAY 85-8050) as a new specific PET tracer was established. Cell-uptake studies revealed specific tumor cell accumulation.

Citation

Raisa N Krasikova, Olga F Kuznetsova, Olga S Fedorova, Yuri N Belokon, Viktor I Maleev, Linjing Mu, Simon Ametamey, P August Schubiger, Matthias Friebe, Mathias Berndt, Norman Koglin, Andre Mueller, Keith Graham, Lutz Lehmann, Ludger M Dinkelborg. 4-[18F]fluoroglutamic acid (BAY 85-8050), a new amino acid radiotracer for PET imaging of tumors: synthesis and in vitro characterization. Journal of medicinal chemistry. 2011 Jan 13;54(1):406-10