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Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains.

Xiao-Zhuo Chen, Peng Xu, Lu Liu, Dan Zheng, Ping-Sheng Lei

Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

European journal of medicinal chemistry 2011 Jan


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  • anti bacterial agents (2)
  • bacteria (1)
  • ketolides (5)
  • macrolide (1)
  • microbial sensitivity tests (1)
  • sulfur (4)
  • telithromycin (1)
    • Sizes of these terms reflect their relevance to your search.

    A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

    Citation

    Xiao-Zhuo Chen, Peng Xu, Lu Liu, Dan Zheng, Ping-Sheng Lei. Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. European journal of medicinal chemistry. 2011 Jan;46(1):208-17

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    PMID: 21130543

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