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A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive and resistant respiratory pathogens. The newly synthesized 9a, 9e, 9k and 9n showed a similar antimicrobial spectrum and comparable activity to telithromycin, the commercial ketolide antibacterial. Copyright © 2010 Elsevier Masson SAS. All rights reserved.


Xiao-Zhuo Chen, Peng Xu, Lu Liu, Dan Zheng, Ping-Sheng Lei. Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains. European journal of medicinal chemistry. 2011 Jan;46(1):208-17

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PMID: 21130543

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