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The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs. Copyright © 2010. Published by Elsevier Ltd.


Finlay W McNab, Ricardo Rajsbaum, Jonathan P Stoye, Anne O'Garra. Tripartite-motif proteins and innate immune regulation. Current opinion in immunology. 2011 Feb;23(1):46-56

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PMID: 21131187

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