A case of fatal drug intoxication showing a high-density duodenal content by postmortem computed tomography.

A 22-year-old woman was found dead in her bed, and subsequent postmortem examination was performed using ordinary methods such as external examination, Triage®, and computed tomography (CT) scan which demonstrated a high-density content of the duodenum. Autopsy and quantitative analysis of drugs present in the GI tract showed that high amounts of radiopaque psychotic agents such as fluvoxamine maleate, carbamazepine, and zolpidem tartrate had been responsible for the high-density profile of the duodenum. Postmortem quantitative analysis of drugs in the blood suggested that death had been caused by fatal intoxication with fluvoxamine maleate. Thus, postmortem CT could offer an opportunity to suspect drug intoxication due to radiopaque psychotic agents such as chloral hydrate, phenothiazine, bromovaleryl urea, fluvoxamine maleate, and probably zolpidem tartrate, although it is neither a specific nor a quantitative test for drugs. Therefore, postmortem CT happened to provide clues to investigation of drug intoxication in the present case. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Citation

Rie Sano, Keiko Takahashi, Yoshihiko Kominato, Takuya Araki, Koujiro Yamamoto, Hiroyuki Takei, Hidenori Otake, Sachiko Awata, Hisashi Akuzawa, Yoko Tago, Hideo Aoki. A case of fatal drug intoxication showing a high-density duodenal content by postmortem computed tomography. Legal medicine (Tokyo, Japan). 2011 Jan;13(1):39-40

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PMID: 21134778

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