Pharmacokinetics and bioavailability of cefquinome in healthy ducks.

Liguo Yuan, Jian Sun, Rui Wang, Lihua Sun, Lixiang Zhu, Xianyang Luo, Binghu Fang, Yahong Liu

Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, People's Republic of China.

American journal of veterinary research 2011 Jan

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To determine pharmacokinetics and bioavailability of cefquinome administered IV, IM, or PO to healthy ducks. Thirty-six 2-month-old Muscovy ducks. Ducks were randomly assigned to 3 groups of 12 birds each for a single IV, IM, or PO administration at a dose of 5 mg/kg. Blood samples were collected before and at various intervals after each administration. Cefquinome concentration was determined by use of high-performance liquid chromatography at 268 nm with a UV detector, and pharmacokinetics were analyzed. The disposition of cefquinome following IV or IM administration was best described by a 2-compartment model. After IV administration, mean ± SD elimination halflife was 1.57 ± 0.06 hours, clearance value was 0.22 ± 0.02 L/kg·h, and apparent volume of distribution at steady state was 0.41 ± 0.04 L/kg. After IM administration, elimination half-life was 1.79 ± 0.13 hours, peak concentration time was 0.38 ± 0.06 hours, peak drug concentration was 9.38 ± 1.61 μg/mL, and absolute mean ± SD bioavailability was 93.28 ± 13.89%. No cefquinome was detected in plasma after PO administration. Results indicated that cefquinome was absorbed quickly and had excellent bioavailability after IM administration, but absorption after PO administration was poor.

Citation

Liguo Yuan, Jian Sun, Rui Wang, Lihua Sun, Lixiang Zhu, Xianyang Luo, Binghu Fang, Yahong Liu. Pharmacokinetics and bioavailability of cefquinome in healthy ducks. American journal of veterinary research. 2011 Jan;72(1):122-6