Paraoxonases as potential antibiofilm agents: their relationship with quorum-sensing signals in Gram-negative bacteria.

Jordi Camps, Isabel Pujol, Frederic Ballester, Jorge Joven, Josep M Simó

Centre de Recerca Biomédica, Laboratori de Microbiologia, and Laboratori de Referéncia de Catalunya, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain. jcamps@grupsagessa.cat

Antimicrobial agents and chemotherapy 2011 Apr

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The property of many bacteria to form biofilms constitutes a major health problem. Bacteria living in biofilms have a very high resistance to antibiotics. Biofilms may develop at a certain locations with the participation of secreted molecules, termed quorum-sensing signals, when a sufficient density of bacterial growth occurs. In Gram-negative bacteria, acyl homoserine lactones (AHL) have been identified as major quorum-sensing signals. The paraoxonases (PONs) constitute a family of enzymes comprising 3 members (PON1, PON2, and PON3) that have lactonase activity and are able to hydrolyze AHL. In this minireview, we summarize some existing basic knowledge on PON genetics, biochemistry, and function and describe recent research that reports evidence of the important roles that they may play in the organism's defense against biofilm formation. Finally, we propose some lines of future research that could be very productive.

Citation

Jordi Camps, Isabel Pujol, Frederic Ballester, Jorge Joven, Josep M Simó. Paraoxonases as potential antibiofilm agents: their relationship with quorum-sensing signals in Gram-negative bacteria. Antimicrobial agents and chemotherapy. 2011 Apr;55(4):1325-31