SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations.

Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Hälsovägen 7, S-141 83 Huddinge, Sweden. Hans.Matsson@ki.se

Behavior genetics 2011 Jan

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Four genes, DYX1C1, ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children. The identification of novel genes is crucial to better understand the molecular pathways affected in dyslectic individuals. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. This region harbours the gene diacylglycerol kinase, iota (DGKI) which contains overlapping haplotypes associated with dyslexia in both Finnish and German sample sets.

Citation

Hans Matsson, Kristiina Tammimies, Marco Zucchelli, Heidi Anthoni, Päivi Onkamo, Jaana Nopola-Hemmi, Heikki Lyytinen, Paavo H T Leppanen, Nina Neuhoff, Andreas Warnke, Gert Schulte-Körne, Johannes Schumacher, Markus M Nöthen, Juha Kere, Myriam Peyrard-Janvid. SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations. Behavior genetics. 2011 Jan;41(1):134-40