Correlation Engine 2.0
Clear Search sequence regions


Sizes of these terms reflect their relevance to your search.

For over five decades, owing to their antiapoptotic activities, bongkrekic and isobongkrekic acids have generated interest from the scientific community. Here, we disclose full details of our investigation into the synthesis of isobongkrekic acid, which culminated in its first preparation and features various palladium-catalysed cross-couplings and Takai olefination reactions. Access to bongkrekic acid is also reported by this route. These syntheses involve the preparation and use of new general building blocks which could find wider applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Antoine Français, Antonio Leyva-Pérez, Gorka Etxebarria-Jardi, Javier Peña, Steven V Ley. Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties. Chemistry (Weinheim an der Bergstrasse, Germany). 2011 Jan 3;17(1):329-43

Expand section icon Mesh Tags

Expand section icon Substances


PMID: 21207629

View Full Text