Thushara Karunasekara, Colin F Poole
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Journal of chromatography. A 2011 Feb 11Partition coefficients for varied compounds were determined for the organic solvent-propylene carbonate biphasic partition system where the organic solvent is n-heptane, isopentyl ether or 1-octanol. These partition coefficient databases are analyzed using the solvation parameter model facilitating a quantitative comparison of the propylene carbonate-based partition systems with other totally organic partition systems. Propylene carbonate is a weak to intermediate cohesive solvent, reasonably dipolar/polarizable and hydrogen-bond basic, and weak hydrogen-bond acidic. Propylene carbonate-organic solvent systems offer a complementary approach to other totally organic biphasic partition systems for sample preparation and descriptor measurements of compounds virtually insoluble or unstable in water. © 2010 Elsevier B.V. All rights reserved.
Thushara Karunasekara, Colin F Poole. Models for liquid-liquid partition in the system propylene carbonate-organic solvent and their use for estimating descriptors for organic compounds. Journal of chromatography. A. 2011 Feb 11;1218(6):809-16
PMID: 21208619
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